Tolvaptan | B2583

Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist (IC₅₀ = 3 nM for rat receptor) and a diuretic agent. It is selective for V2 over V1 receptors (IC₅₀ = 0.58 μM). Used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).

Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist (IC₅₀ = 3 nM for rat receptor) and a diuretic agent. It is selective for V2 over V1 receptors (IC₅₀ = 0.58 μM). Used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).

B2583 | Tolvaptan DataSheet

Alternate Name/Synonyms: OPC-41061, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-benzamide, OPC 41061, OPC41061

Appearance: White to off-white solid

Formulation:

CAS Number: 150683-30-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₅ClN₂O₃

Molecular Weight: 448.94

Cell-Permeable?: False

Purity: ≥98%

Solubilities: >100 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: a selective, A competitive arginine vasopressin V2 receptor antagonist

MDL Number:

PubChem CID: 216237

SMILES: CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C

InChi: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

InChi Key: