TOP2A Antibody (C-term) [APR06153G]

TOP2A Antibody (C-term) [APR06153G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TOP2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1167-1196 amino acids from the C-terminal region of human TOP2A.

Cellular Localisation: Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus

Molecular Weight: 174385

Clone: Polyclonal

Gene Name: TOP2A

Gene ID: 7153

Function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612) . May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity) .

Summary: Tissue Location: Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056) . Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, IF

Dilution: WB--1:2000

Synonyms: DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2