LBD
TOP2A Antibody (C-term) [APR06153G]
- SKU:
- LBD-APR06153G
- Availability:
- Usually ships in 5 working days
Description
TOP2A Antibody (C-term) [APR06153G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TOP2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1167-1196 amino acids from the C-terminal region of human TOP2A.
Cellular Localisation: Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus
Molecular Weight: 174385
Clone: Polyclonal
Gene Name: TOP2A
Gene ID: 7153
Function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612) . May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity) .
Summary: Tissue Location: Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056) . Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, IF
Dilution: WB--1:2000
Synonyms: DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2