TOP3A polyclonal Antibody | BS60749

TOP3A polyclonal Antibody | BS60749 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils. Topo IIIα exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIα, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. Topo IIIβ exists as three isoforms,β-1,β -2 and β-3, also produced by alternative splicing. Topo IIIβ-1 is expressed in testis, heart, and skeletal muscle, whereas Topo IIIβ-2 is expressed in thymus, kidney and pancreas.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TOP3A polyclonal Antibody detects endogenous levels of TOP3A protein.

Molecular Weight: ~ 112 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DNA topoisomerase 3-alpha; DNA topoisomerase III alpha; TOP3A; TOP3

Immunogen: A synthetic peptide corresponding to residues in Human TOP3A

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A