Torin 2 | 2274

A potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to 440 other protein kinases.

Torin 2 is a potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 2.1 nM for mTORC1).

2274 | Torin 2 DataSheet

Alternate Name/Synonyms: 9-(6-Amino-3-pyridinyl)-1-[3-(trifl­uoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)­-one

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1223001-51-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₅F₃N₄O

Molecular Weight: 432.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~8 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent mTOR inhibitor

MDL Number: MFCD18782652

PubChem CID: 51358113

SMILES: C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F

InChi: InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)

InChi Key: GUXXEUUYCAYESJ-UHFFFAOYSA-N