Tozasertib (VX-680, MK-0457, VX6) | 1595

Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.

Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.

1595 | Tozasertib (VX-680, MK-0457, VX6) DataSheet

Alternate Name/Synonyms: MK-0457, VX6, VX-680

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 639089-54-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₈N₈OS

Molecular Weight: 464.59

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (100 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An Aurora kinase inhibitor

MDL Number: MFCD10565966

PubChem CID: 5494449

SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

InChi: InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12- 31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H, 3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)

InChi Key: GCIKSSRWRFVXBI-UHFFFAOYSA-N