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Tozasertib (VX-680, MK-0457, VX6) | 1595
- SKU:
- 26-1595-GEN
- Availability:
- Usually shipped in 5 working days
Description
Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.
Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.
1595 | Tozasertib (VX-680, MK-0457, VX6) DataSheet
Alternate Name/Synonyms: MK-0457, VX6, VX-680
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 639089-54-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₈N₈OS
Molecular Weight: 464.59
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (100 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: An Aurora kinase inhibitor
MDL Number: MFCD10565966
PubChem CID: 5494449
SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
InChi: InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12- 31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H, 3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
InChi Key: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
RT |
Shelf Life: |
24months |