TPH1 polyclonal Antibody | BS91370

TPH1 polyclonal Antibody | BS91370 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC IP FC

Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, L-DOPA, which is used as a common therapy for Parkinson’s disease (PD) patients, inhibits TPH function, which subsequently, is thought to contribute to the onset of depression in PD patients.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TPH1 polyclonal Antibody detects endogenous levels of TPH1 protein.

Molecular Weight: 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TPH1, Indoleacetic acid 5 hydroxylase, L tryptophan hydroxylase, MGC119994, TPH 1, TPH, TPH1, TPH1, TPRH, TRPH, Tryptophan 5 hydroxylase 1, Tryptophan 5 monooxygenase 1, Tryptophan 5 monooxygenase, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: