TPPP Polyclonal Antibody | E-AB-18394

TPPP Polyclonal Antibody | E-AB-18394 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 25 kDa brain specific protein , 25 kDa brain-specific protein, Brain specific protein p25 alpha, Glycogen synthase kinase 3 (GSK3) inhibitor p24, OTTHUMP00000161630, p24, p25, p25-alpha, p25alpha , TPPP, TPPP/p25, TPPP, TPPP1, Tubulin polymerization promoting protein, Tubulin polymerization-promoting protein

Application: WB, IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Signal transduction

Background: Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Concentration: 0.8 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Full length fusion protein

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 24 kDa

Molecular Weight(Observed): Refer to figures