TPT1 Antibody | 7193

TPT1 Antibody | 7193 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Rabbit: (100%) , Bovine: (100%) , Pig: (100%) , Chicken: (74%)

Immunogen: Rabbit polyclonal TPT1 antibody was raised against a 19 amino acid peptide near the center of human TPT1.
The immunogen is located within amino acids 80 - 130 of TPT1.

Research Area: Immunology

Tested Application: E, WB, IHC-P, IF

Application: TPT1 antibody can be used for detection of TPT1 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 19 kDa

Validation: N/A

Isoform: N/A

Purification: TPT1 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TPT1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TPT1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: TPT1 Antibody: HRF, p02, p23, TCTP, Translationally-controlled tumor protein, Fortilin

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TPT1 Antibody: TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer’s disease and Down syndrome.