Tranilast | 1876

Cell-permeable. A potent angiogenesis inhibitor. Inhibits VEGF-induced angiogenetic activities. Displays anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.

Tranilast is a potent angiogenesis inhibitor. Inhibits VEGF-induced angiogenetic activities. Displays anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.

1876 | Tranilast DataSheet

Alternate Name/Synonyms: 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid; SB 252218

Appearance: Yellow solid

Formulation: N/A

CAS Number: 53902-12-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₇NO₅

Molecular Weight: 327.33

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent angiogenesis inhibitor.

MDL Number: MFCD00864787

PubChem CID: 5282230

SMILES: COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC

InChi: InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+

InChi Key: NZHGWWWHIYHZNX-CSKARUKUSA-N