trans-ISRIB | B1906

trans-ISRIB is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation (IC₅₀ = 5 nM). Enhances spatial and fear-associated learning in mice and enhances cognitive function. Mechanism of action involves activation of eiF2β. Suppresses ER stress-induced inflammatory gene expression. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.

trans-ISRIB is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation (IC₅₀ = 5 nM). Enhances spatial and fear-associated learning in mice and enhances cognitive function. Mechanism of action involves activation of eiF2β. Suppresses ER stress-induced inflammatory gene expression. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.

B1906 | trans-ISRIB DataSheet

Alternate Name/Synonyms: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]; ISRIB

Appearance: White solid

Formulation: N/A

CAS Number: 1597403-47-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₄Cl₂N2₂O₄

Molecular Weight: 451.3

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An integrated stress response inhibitor

MDL Number: N/A

PubChem CID: 1011240

SMILES: C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl

InChi: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)

InChi Key: HJGMCDHQPXTGAV-UHFFFAOYSA-N