TRIB1 Antibody (C-term) [APR06003G]

TRIB1 Antibody (C-term) [APR06003G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TRIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human TRIB1.

Cellular Localisation: N/A

Molecular Weight: 41009

Clone: Polyclonal

Gene Name: TRIB1 (HGNC:16891)

Gene ID: 10221

Function: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596) . The COP1- binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797) . Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596) . Binds selectively the recognition sequence of CEBPA (PubMed:26455797) . Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity) . Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity) . Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797) .

Summary: Tissue Location: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, GIG-2, SKIP1, TRIB1 (HGNC:16891)