LBD
TRIB1 Antibody (C-term) [APR06003G]
- SKU:
- LBD-APR06003G
- Availability:
- Usually ships in 5 working days
Description
TRIB1 Antibody (C-term) [APR06003G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TRIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human TRIB1.
Cellular Localisation: N/A
Molecular Weight: 41009
Clone: Polyclonal
Gene Name: TRIB1 (HGNC:16891)
Gene ID: 10221
Function: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596) . The COP1- binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797) . Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596) . Binds selectively the recognition sequence of CEBPA (PubMed:26455797) . Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity) . Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity) . Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797) .
Summary: Tissue Location: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, GIG-2, SKIP1, TRIB1 (HGNC:16891)