Triclabendazole | B3038

Triclabendazole is a benzimidazole anthelminthic drug that binds to tubulin. TCBZ is used to treat liver fluke (Fasciola hepatica) infections in cattle and humans. It is effective against fascioliasis in sheep at a dose of 10 mg/body weight. Triclabendazole (5 μM) protects yeast cells from death induced by α-synuclein, oxidants and heat stress. It decreases the intracellular level of cyclic AMP and triggers the translocation of the stress-resistance transcription factor Msn2 from the cytosol into the nucleus in yeast cells.

Triclabendazole is a benzimidazole anthelminthic drug that binds to tubulin. TCBZ is used to treat liver fluke (Fasciola hepatica) infections in cattle and humans. It is effective against fascioliasis in sheep at a dose of 10 mg/body weight. Triclabendazole (5 μM) protects yeast cells from death induced by α-synuclein, oxidants and heat stress. It decreases the intracellular level of cyclic AMP and triggers the translocation of the stress-resistance transcription factor Msn2 from the cytosol into the nucleus in yeast cells.

B3038 | Triclabendazole DataSheet

Alternate Name/Synonyms: Fasinex; 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzimidazole; 5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole

Appearance: White to Off-White Powder

Formulation:

CAS Number: 68786-66-3

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₄H₉Cl₃N₂OS

Molecular Weight: 359.66

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~3.6 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A benzimidazole anthelminthic drug that binds to tubulin

MDL Number: MFCD00864519

PubChem CID: 50248

SMILES: CSC1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl

InChi: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

InChi Key: NQPDXQQQCQDHHW-UHFFFAOYSA-N