Trigonelline Chloride | B2606

Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals. Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes. Trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis.

Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals. Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes. Trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis.

B2606 | Trigonelline Chloride DataSheet

Alternate Name/Synonyms: 3-carboxy-1-methyl-pyridinium, monochloride, N-methyl Nicotinic Acid betaine

Appearance: Crystalline solid

Formulation:

CAS Number: 6138-41-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₇H₈NO₂ • Cl

Molecular Weight: 173.6

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~ 5 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An anti-diabetic agent

MDL Number: MFCD00077250

PubChem CID: 134606

SMILES: OC(C1=C[N+](C)=CC=C1)=O.[Cl-]

InChi: InChI=1S/C7H7NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h2-5H,1H3;1H

InChi Key: TZSYLWAXZMNUJB-UHFFFAOYSA-N