LBD
TRIM6Antibody (N-term) [APR04586G]
- SKU:
- LBD-APR04586G
- Availability:
- Usually ships in 5 working days
Description
TRIM6Antibody (N-term) [APR04586G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TRIM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human TRIM6.
Cellular Localisation: Cytoplasm
Molecular Weight: 56400
Clone: Polyclonal
Gene Name: TRIM6
Gene ID: 117854
Function: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218, PubMed:31694946) . In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys- 48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218) . Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Tripartite motif-containing protein 6, RING finger protein 89, TRIM6, RNF89