Tripolin A | 2307

A specific non-ATP competitive Aurora A kinase inhibitor. Does not significantly inhibit Aurora B kinase in mammalian cells. Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase.

Tripolin A is a specific non-ATP competitive Aurora A kinase inhibitor. Does not significantly inhibit Aurora B kinase in mammalian cells

2307 | Tripolin A DataSheet

Alternate Name/Synonyms: (3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1148118-92-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₁NO₃

Molecular Weight: 253.25

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An Aurora kinase A inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: OC1=CC=C(O)C=C1/C=C(C2=C(N3)C=CC=C2)\C3=O

InChi: InChI=1S/C15H11NO3/c17-10-5-6-14(18)9(7-10)8-12-11-3-1-2-4-13(11)16-15(12)19/h1-8,17-18H,(H,16,19)/b12-8-

InChi Key: OMKSBDLWMROKNU-WQLSENKSSA-N