TrkA/B/C polyclonal Antibody | BS91375

TrkA/B/C polyclonal Antibody | BS91375 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC

Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. In the adult nervous system, the Trk receptors regulate synaptic strength and plasticity. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions, and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA. TrkA is activated in many malignancies including breast, ovarian, prostate, and thyroid carcinomas. TrkB is overexpressed in tumors such as neuroblastoma, prostate adenocarcinoma and pancreatic ductal adenocarcinoma. In neuroblastomas overexpression of TrkB correlates with unfavorable disease outcome when autocrine loops signaling tumor survival are potentiated by additional overexpression of brain-derived neurotrophic factor (BDNF) . An alternatively spliced truncated TrkB isoform lacking the kinase domain is overexpressed in Wilms’ tumors and this isoform may act as a dominant-negative to TrkB signaling. Altered TrkC expression and corresponding gene mutations are seen in various forms of cancer, with increased expression a positive prognostic indicator in patients with medulloblastoma.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TrkA/B/C polyclonal Antibody detects endogenous levels of TrkA/B/C protein.

Molecular Weight: 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Trk-A, NTRK1, Trk-B, NTRK2, Trk-C, NTRK3, BDNF/NT-3 growth factors receptor, gp140trk, GP145-TrkB, GP145-TrkC, High affinity nerve growth factor receptor, MTC, Neurotrophic tyrosine kinase receptor type 1, Neurotrophic tyrosine kinase receptor type 2, Neurotrophic tyrosine kinase receptor type 3, NT-3 growth factor receptor, NTRK1, NTRK2, NTRK3, p140-TrkA, TRK, Trk-A, Trk-B, Trk-C, TRK1-transforming tyrosine kinase protein, TRKA, TRKB, TrkB tyrosine kinase, TRKC, TrkC tyrosine kinase, Tropomyosin-related kinase A, Tropomyosin-related kinase B, Tyrosine kinase receptor A, Tyrosine kinase receptor,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: