TRMT1 polyclonal Antibody | BS70769

TRMT1 polyclonal Antibody | BS70769 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background: N (2),N (2) -dimethylguanosine tRNA methyltransferase, also known as TRMT1 or tRNA (guanine-26,N (2) -N (2) ) methyltransferase, is a 659 amino acid enzyme that is responsible for tRNA modifications in eukaryotes. Using S-adenosyl-L-methionine as a methyl donor, TRMT1 dimethylates a single guanine residue at position 26 of tRNA. TRMT1, which was initially identified in yeast and C. elegans, has a 26% and 31% sequence identity to its yeast and C. elegans homologs, respectively. There are two isoforms of TRMT1 produced by alternative splicing events. The TRMT1 gene maps to chromosome 19p13.13 and mutations in this gene lead to abrogated enzyme activity and a decrease in protein levels.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TRMT1 polyclonal Antibody detects endogenous levels of TRMT1 protein.

Molecular Weight: ~ 90 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TRM1; tRNA (guanine (26) -N (2) ) -dimethyltransferase

Immunogen: Recombinant protein of human TRMT1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: