TRPM4 monoclonal Antibody | MB65504

TRPM4 monoclonal Antibody | MB65504 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Monkey, Dog

Application: IHC, WB

Application Range: WB 1:5000~10000, IHC 1:50

Background: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca (2+), it is impermeable to it. Mediates transport of monovalent cations (Na (+) > K (+) > Cs (+) > Li (+) ), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca (2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca (2+) overload.

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: transient receptor potential cation channel subfamily M member 4

Molecular Weight: 134.3 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hTRPM4; LTrpC4; PFHB1B; TRPM4B

Immunogen: Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A