LBD
TTC35 Antibody (Center) [APR04310G]
- SKU:
- LBD-APR04310G
- Availability:
- Usually ships in 5 working days
Description
TTC35 Antibody (Center) [APR04310G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This TTC35 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the Central region of human TTC35.
Cellular Localisation: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Note=May also localize to the nuclear envelope {ECO:0000250|UniProtKB:Q9CRD2}
Molecular Weight: 34834
Clone: Polyclonal
Gene Name: EMC2 (HGNC:28963)
Gene ID: 9694
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656) . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231) . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151) . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231) . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N- terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835) . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: ER membrane protein complex subunit 2, Tetratricopeptide repeat protein 35, TPR repeat protein 35, EMC2, KIAA0103, TTC35