Tuberin polyclonal Antibody | BS91384

Tuberin polyclonal Antibody | BS91384 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC FC

Application Range: WB:1:1,000-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Tuberin polyclonal Antibody detects endogenous levels of Tuberin protein.

Molecular Weight: 200 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TSC2, TSC4, FLJ43106, LAM, OTTHUMP00000158940, OTTHUMP00000198394, OTTHUMP00000198395, PPP1R160, Protein phosphatase 1, regulatory subunit 160, tsc2, TSC2, TSC4, TSC4 gene, formerly, TSC4, formerly, Tuberin, Tuberous sclerosis 2, Tuberous sclerosis 2 protein, Tuberous sclerosis 2 protein homolog,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: