TUBGCP4 Polyclonal Antibody | E-AB-52657

TUBGCP4 Polyclonal Antibody | E-AB-52657 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 76P, FLJ14797, Gamma tubulin complex component 4, Gamma tubulin ring complex protein (76p gene), Gamma tubulin ring complex protein, Gamma-ring complex protein 76 kDa, GCP 4, GCP4, Grip76, h76p, hGCP4, Hgrip76, TUBGCP 4, TUBGCP4, Tubulin gamma complex associated protein 4

Application: WB, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Signal Transduction

Background: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants.TUBGCP4 (Tubulin Gamma Complex Associated Protein 4) is a Protein Coding gene. Diseases associated with TUBGCP4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 3 and Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is TUBGCP6.

Concentration: 0.66 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human TUBGCP4

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 76 kDa

Molecular Weight(Observed): Refer to figures