TUG-770 | B1166

TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC₅₀ of 6 nM for hFFA1.The FFA1 increases glucose stimulated insulin secretion from pancreatic β-cells and efficiently maintains normal glucose level in diet induced obese mice with fully sustained effect after 29 days of chronic dosing.

TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC₅₀ of 6 nM for hFFA1.The FFA1 increases glucose stimulated insulin secretion from pancreatic β-cells and efficiently maintains normal glucose level in diet induced obese mice with fully sustained effect after 29 days of chronic dosing.

B1166 | TUG-770 DataSheet

Alternate Name/Synonyms: 3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid

Appearance: Light Yellow Solid

Formulation: N/A

CAS Number: 1402601-82-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₄FNO₂

Molecular Weight: 307.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist

MDL Number: N/A

PubChem CID: 66553168

SMILES: C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F

InChi: 1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)

InChi Key: KIZUBVPJNPVIIN-UHFFFAOYSA-N