Description
TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC₅₀ of 6 nM for hFFA1.The FFA1 increases glucose stimulated insulin secretion from pancreatic β-cells and efficiently maintains normal glucose level in diet induced obese mice with fully sustained effect after 29 days of chronic dosing.
TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC₅₀ of 6 nM for hFFA1.The FFA1 increases glucose stimulated insulin secretion from pancreatic β-cells and efficiently maintains normal glucose level in diet induced obese mice with fully sustained effect after 29 days of chronic dosing.
Alternate Name/Synonyms: 3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid
Appearance: Light Yellow Solid
Formulation: N/A
CAS Number: 1402601-82-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₄FNO₂
Molecular Weight: 307.32
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>3 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist
MDL Number: N/A
PubChem CID: 66553168
SMILES: C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F
InChi: 1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)
InChi Key: KIZUBVPJNPVIIN-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |