TXNL1 polyclonal Antibody | BS8129

TXNL1 polyclonal Antibody | BS8129 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Thioredoxins are small redox active proteins that play a variety of roles throughout the cell. TXNL1 (Thioredoxin-like protein 1), also known as TRP32, TXL or TXL-1, is a 289 amino acid cytoplasmic protein that is thought to participate in endocytotic signaling pathways and may act as a redox sensor. Expressed throughout the body, TXNL1 functions to couple oxidative stress to endocytosis, thereby regulating the GDI:Rad5-mediated endocytic response. Additionally, overexpression of TXNL1 inhibits cell proliferation by predisposing the cell to G0/G1 arrest, suggesting that TXNL1 also functions as a transcriptional repressor. TXNL1 shares 99% homology with its mouse homolog and contains one thioredoxin domain.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TXNL1 polyclonal Antibody detects endogenous levels of TXNL1 protein.

Molecular Weight: ~ 32 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Thioredoxin-like protein 1; 32 kDa thioredoxin-related protein; TXNL1; TRP32; TXL; TXNL

Immunogen: Recombinant TXNL1 protein, corresponding to amino acids 1-289 of Human LGR5.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: