TYMS polyclonal Antibody | BS91392

TYMS polyclonal Antibody | BS91392 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC IP FC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Background: Thymidylate synthase (TS), also designated TYMS, TMS, TSase and HsT422, uses 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor in the synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor for DNA biosynthesis. TS is an RNA-binding protein that can interact with its own mRNA. The TS/mRNA ribonucleoprotein complex can also associate with a number of other cellular mRNAs, including those corresponding to the p53 tumor suppressor gene and the Myc family of transcription factors. Inhibition of DNA replication and cell death resulting from thymidine depletion occurs when TS enzyme activity is inhibited with substrate or cofactor analogs, making the TS enzyme an important target for chemotherapy. Cancer cells are sensitive to thymidine depletion, as they multiply rapidly.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TYMS polyclonal Antibody detects endogenous levels of TYMS protein.

Molecular Weight: 36 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TS, TSase, TYMS, OK/SW-cl.29, d TMP synthase, EC 2.1.1.45, HsT422, MGC88736, OTTHUMP00000162195, Thymidylate synthase, Thymidylate synthetase, TMS, TS, TSase, Tyms, TYMS protein, Tyms thymidylate synthetase, TYSY,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: