U-104 | 9631

U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM). It displays weaker affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.

U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM). It displays weaker affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.

9631 | U-104 DataSheet

Alternate Name/Synonyms: 1-(4-fluorophenyl)-3-(4-sulfamoylphenyl)urea; NSC-213841

Appearance: White solid

Formulation: N/A

CAS Number: 178606-66-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₂FN₃O₃S

Molecular Weight: 309.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A transmembrane carbonic anhydrase IX (CAIX)

MDL Number: MFCD00159265

PubChem CID: 310360

SMILES: C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F

InChi: InChI=1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)

InChi Key: YJQZNWPYLCNRLP-UHFFFAOYSA-N