U-73122 | B1887

U-73122 is an Inhibitor of receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction. A useful tool for probing the involvement of phospholipase C in receptor mediated cellular signaling and physiology. It also displays inhibitory activity against HIV-1 integrase (IC₅₀ = 7 µM). Cell permeable.

U-73122 is an Inhibitor of receptor-coupled phospholipase C-dependent processes in platelets and neutrophils via interfering with G protein-PLC interaction. A useful tool for probing the involvement of phospholipase C in receptor mediated cellular signaling and physiology. It also displays inhibitory activity against HIV-1 integrase (IC₅₀ = 7 µM). Cell permeable.

B1887 | U-73122 DataSheet

Alternate Name/Synonyms: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

Appearance: White to of-white solid

Formulation: N/A

CAS Number: 112648-68-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₄₀N₂O₃

Molecular Weight: 464.64

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (2 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A phospholipase C inhibitor

MDL Number: MFCD12910450

PubChem CID: 104794

SMILES: CC12CCC3C(C1CCC2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC

InChi: InChI=1S/C29H40N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1

InChi Key: LUFAORPFSVMJIW-ZRJUGLEFSA-N