UBE2D4 polyclonal Antibody | BS71166

UBE2D4 polyclonal Antibody | BS71166 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free, or covalently attached, to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign and improperly folded proteins by targeting them for proteosomal degradation. UBE2D proteins, including UBE2D1 (ubiquitin-conjugating enzyme E2D1), UBE2D2 (ubiquitin-conjugating enzyme E2D2), UBE2D3 (ubiquitin-conjugating enzyme E2D3) and UBE2D4 (ubiquitin-conjugating enzyme E2D4, also known as HBUCE1), are E2 ubiquitin-conjugating enzymes that catalyze the ubiquitination of target proteins in an ATP-dependent manner. Specifically, an E1 enzyme first transfers a ubiquitin residue to an E2 component (a UBE2D protein), and the UBE2D protein then associates with an E3 ubiquitin-protein ligase, which immediately transfers that residue to a protein that is targeted for degradation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: UBE2D4 polyclonal Antibody detects endogenous levels of UBE2D4 protein.

Molecular Weight: ~ 17 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HBUCE1;

Immunogen: Recombinant protein of human UBE2D4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: TGFβ Smad signaling,