UBE2V1 polyclonal Antibody | BS8126

UBE2V1 polyclonal Antibody | BS8126 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Uev1A, also designated Uev1, UBE2V1 for Ubiquitin-conjugating enzyme E2 variant 1 and CROC1, shows sequence similarity to other ubiquitin-conjugating enzymes, but lacks the conserved cysteine residue critical for their catalytic activity . Therefore, Uev1A does not have ubiquitin-conjugating activity in vitro . However, constitutive expression of exogenous Uev1A in colon carcinoma cells inhibits their capacity to differentiate upon confluence. Studies on recombinant Uev1A show that it localizes to the nucleus, excluding the nucleolar regions . Uev1A functions with TRAF6, a RING domain protein, to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 of ubiquitin . The gene encoding Uev1A maps to human chromosome 20q13.2 .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: UBE2V1 polyclonal Antibody detects endogenous levels of UBE2V1 protein.

Molecular Weight: ~ 16 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A; UBE2V1; CROC1; UBE2V; UEV1; P/OKcl.19

Immunogen: Recombinant full length Human UBE2V1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: