UBE4B Antibody (N-term) [APR31944G]

UBE4B Antibody (N-term) [APR31944G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This UBE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-142 amino acids from the N-terminal region of human UBE4B.

Cellular Localisation: Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q9ES00}

Molecular Weight: 146185

Clone: Polyclonal

Gene Name: UBE4B (HGNC:12500)

Gene ID: 10277

Function: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity) . May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity) . May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820) .

Summary: Tissue Location: Expressed in differentiated myotubes (at protein level) (PubMed:17369820) . Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788) . Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788) . Almost undetectable in lung and spleen (PubMed:11802788)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P-Leica

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Ubiquitin conjugation factor E4 B, 632-, UBE4B (HGNC:12500)