UBXN6 Antibody (C-term) [APR05477G]

UBXN6 Antibody (C-term) [APR05477G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This UBXN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the C-terminal region of human UBXN6.

Cellular Localisation: Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546) . May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278) . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622)

Molecular Weight: 49754

Clone: Polyclonal

Gene Name: UBXN6 (HGNC:14928)

Gene ID: 80700

Function: May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856) . As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559) . It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885) . Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622) .

Summary: Tissue Location: Enhanced expression in testis.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:2000 WB--1:1000 IHC-P--1:100~500

Synonyms: UBX domain-containing protein 6, UBX domain-containing protein 1, UBXN6, UBXD1, UBXDC2