UGT2B28 Antibody (Center) [APR10635G]

UGT2B28 Antibody (Center) [APR10635G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This UGT2B28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human UGT2B28.

Cellular Localisation: Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm, perinuclear region

Molecular Weight: 60906

Clone: Polyclonal

Gene Name: UGT2B28 (HGNC:13479)

Gene ID: 54490

Function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:11300766) . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:11300766) . Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) (PubMed:11300766) . Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption (PubMed:11300766) . Displays glucuronidation activity toward the phenolic compounds eugenol (PubMed:11300766) .

Summary: Tissue Location: Expressed in the liver, breast and kidney.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: UDP-glucuronosyltransferase 2B28, UDPGT 2B28, UGT2B28