UHRF1 Monoclonal Antibody (Clone M02) | A2308

UHRF1 belongs to a subfamily of RING-finger type E3 ubiquitin ligases. In addition to its action as a E3 ubiquitin-protein ligase for target proteins such as histone H3 and PML, UHRF1 also binds to specific DNA sequences. UHRF1 recruits histone deacetylaase to regulate gene expression. The expression of UHRF1 peaks during late G1 and persists through G2 and M phases of the cell cycle, playing a key role in the G1/S transition through its regulation of retinoblastoma and topoisomerase. UHRF1 also participates in the p53-dependent DNA damage checkpoint. UHRF1 is considered as a therapeutic target as it is upregulated in various cancers, including colorectal cancer.

A2308 | UHRF1 Monoclonal Antibody (Clone M02) DataSheet

Antibody Target: Human UHRF1

Target Alternative Name: Ubiquitin Like With PHD And Ring Finger Domains 1; ICBP90; RNF106; Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 1; Inverted CCAAT Box-Binding Protein Of 90 kDa; RING-Type E3 Ubiquitin Transferase UHRF1; E3 Ubiquitin-Protein Ligase UHRF1; Nuclear Zinc Finger Protein Np95; Transcription Factor ICBP90; RING Finger Protein 106; Nuclear Protein 95; TDRD22; HUHRF1; HuNp95; Np95; Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 1; Nuclear Phosphoprotein 95; EC 2.3.2.27; FLJ21925; EC 6.3.2; HNP95

Tag Line: A critical cell cycle regulator

Category: GM-CSF

Host: Mouse

Isotype: Mouse IgG1 kappa

Species Reactivities: Human

Immunogen Sequence: GST-tagged human UHRF1 partial recombinant protein (amino acid 694 to 793)

Accession #: Q96T88

Gene ID: 29128

Appearance: Liquid

Form: Mouse monoclonal

Concentration:

Formulation: In PBS pH 7.2

Purification:

Application: Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE