UHRF1 (N-terminus) monoclonal Antibody | MB0055

UHRF1 (N-terminus) monoclonal Antibody | MB0055 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human,Mouse

Application: WB ICC

Application Range: WB: 1:1000 ICC: 1:50~200

Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of UHRF1 (N-terminus) and does not cross-react with related proteins

Molecular Weight: Predicted band size:90KDa Observed band size:90KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Np95; hNP95; ICBP90; RNF106; FLJ21925; MGC138707; E3 ubiquitin-protein ligase UHRF1; Nuclear protein 95; HuNp95; hNp95; RING finger protein 106;

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human UHRF1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: