UK-5099 | B1952

UK-5099 is a potent and specific inhibitor of MPC (mitochondrial pyruvate carrier) activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with an IC₅₀ value of 50 nM. UK-5099 has recently been shown to block pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice.

UK-5099 is a potent and specific inhibitor of MPC (mitochondrial pyruvate carrier) activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with an IC₅₀ value of 50 nM. UK-5099 has recently been shown to block pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice.

B1952 | UK-5099 DataSheet

Alternate Name/Synonyms: 2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

Appearance: Yellow solid

Formulation: N/A

CAS Number: 56396-35-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₂N₂O₂

Molecular Weight: 288.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and specific MPC (mitochondrial pyruvate carrier) activity inhibitor

MDL Number: MFCD19443867

PubChem CID: 6438504

SMILES: C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)C=C(C#N)C(=O)O

InChi: InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+

InChi Key: BIZNHCWFGNKBBZ-JLHYYAGUSA-N