ULK1 polyclonal Antibody | BS91404

ULK1 polyclonal Antibody | BS91404 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200

Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: ULK1 polyclonal Antibody detects endogenous levels of ULK1 protein.

Molecular Weight: 112 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ATG1, hATG1, ULK1, KIAA0722, ATG 1, ATG1, ATG1 autophagy related 1 homolog, ATG1A, Autophagy related protein 1 homolog, Autophagy-related protein 1 homolog, FLJ38455, FLJ46475, hATG1, KIAA0722, Serine/threonine protein kinase ULK1, Serine/threonine protein kinase Unc51.1, Serine/threonine-protein kinase ULK1, ULK 1, ULK1, ULK1, Unc 51 (C. elegans) like kinase 1, UNC 51, Unc 51 like kinase 1, Unc-51 like kinase 1 (C. elegans), Unc-51-like kinase 1, UNC51, UNC51, C. elegans, homolog of, Unc51.1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: