UMI-77 | B1108

UMI-77 is a novel, selective, Mcl-1 SMI inhibitor. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. It inhibits cell growth and induces apoptosis in pancreatic cancer cells.

UMI-77 is a novel, selective, Mcl-1 SMI inhibitor. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. It inhibits cell growth and induces apoptosis in pancreatic cancer cells.

B1108 | UMI-77 DataSheet

Alternate Name/Synonyms: 2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 518303-20-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₄BrNO₅S₂

Molecular Weight: 468.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A novel, selective, Mcl-1 SMI inhibitor

MDL Number: MFCD03471890

PubChem CID: 992586

SMILES: C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br

InChi: InChI=1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)

InChi Key: WUGANDSUVKXMEC-UHFFFAOYSA-N