UNC 1215 | 2252

Cell-permeable. A potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting transcriptional repressors. It binds L3MBTL3 with a Kd value of 120 nM (IC₅₀ = 40 nM), competitively displacing mono- or dimethyl-lysine containing peptides. UNC1215 is > 50-fold selective toward L3MBTL3 than other members of the human MBT family and demonstrates selectivity against more than 200 other Kme reader domains examined.

UNC 1215 is a potent L3MBTL3 domain inhibitor (IC₅₀ = 20 nM; Kd = 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors.

2252 | UNC 1215 DataSheet

Alternate Name/Synonyms: (2-​(Phenylamino)-​1,​4-​phenylene)bis((4-​(pyrrolidin-​1-​yl)piperidin-​1-​yl)methanone

Appearance: White to Off-white Solid

Formulation: N/A

CAS Number: 1415800-43-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₄₃N₅O₂

Molecular Weight: 529.72

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent L3MBTL3 domain inhibitor

MDL Number: N/A

PubChem CID: 57339144

SMILES: C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6

InChi: InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2

InChi Key: PQOOIERVZAXHBP-UHFFFAOYSA-N