UNC-669 | 2620

UNC-669 is a small molecule nicotinamide derivative that acts asan antagonist of the MBT(Malignant Brain Tumor) domain, a family of methyl-lysine binding reader proteins. UNC669 displays selectivity for L3MBTL3 (IC₅₀ = 3.1 µM) and L3MBTL1(IC₅₀ = 4.2 µM) over L3MBTL4 (IC₅₀ = >10 µM).

UNC-669 is a small molecule nicotinamide derivative that acts asan antagonist of the MBT(Malignant Brain Tumor) domain, a family of methyl-lysine binding reader proteins. UNC669 displays selectivity for L3MBTL3 (IC₅₀ = 3.1 µM) and L3MBTL1(IC₅₀ = 4.2 µM) over L3MBTL4 (IC₅₀ = >10 µM).

2620 | UNC-669 DataSheet

Alternate Name/Synonyms: (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)

Appearance: Pale orange yellow solid

Formulation: N/A

CAS Number: 1314241-44-5

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₀BrN₃O

Molecular Weight: 338.24

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A MBT domain antagonist

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(C1=CC(Br)=CN=C1)N2CCC(N3CCCC3)CC2

InChi: InChI=1S/C15H20BrN3O/c16-13-9-12(10-17-11-13)15(20)19-7-3-14(4-8-19)18-5-1-2-6-18/h9-11,14H,1-8H2

InChi Key: CQERVFFAOOUFEQ-UHFFFAOYSA-N