UNC0224 | B2823

UNC0224 is a selective G9a Histone Methyltransferase inhibitor. G9a methylates Histone H3 lysine 9, which is required for early embryogenesis. UNC0224 inhibits G9a with an IC₅₀ of 15 nM. It also inhibits GLP, another H3K9 methyltransferase with an IC₅₀ of 20 nM.

UNC0224 is a selective G9a Histone Methyltransferase inhibitor. G9a methylates Histone H3 lysine 9, which is required for early embryogenesis. UNC0224 inhibits G9a with an IC₅₀ of 15 nM. It also inhibits GLP, another H3K9 methyltransferase with an IC₅₀ of 20 nM.

B2823 | UNC0224 DataSheet

Alternate Name/Synonyms: 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine; N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294; 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine; Histone Lysine Methyltransferase Inhibitor V

Appearance: Crystalline solid

Formulation:

CAS Number: 1197196-48-7

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₆H₄₃N₇O₂

Molecular Weight: 485.67

Cell-Permeable?: False

Purity: ≥98%

Solubilities: ~2.5 mg/ml in PBS, pH 7.2 in 0, ~15 mg/ml in in Ethanol, ~2 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A G9a Histone Methyltransferase inhibitor

MDL Number: MFCD18251564

PubChem CID: 44251522

SMILES: CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCN(C)C

InChi: InChI=1S/C26H43N7O2/c1-30(2)10-7-17-35-24-19-22-21(18-23(24)34-5)25(27-20-8-13-32(4)14-9-20)29-26(28-22)33-12-6-11-31(3)15-16-33/h18-20H,6-17H2,1-5H3,(H,27,28,29)

InChi Key: XIVUGRBSBIXXJE-UHFFFAOYSA-N