UNC2250 | B3111

UNC2250 is an inhibitor of Mer receptor tyrosine kinase. It inhibits steady-state phosphorylation of endogenous Mer with an IC₅₀ of 9.8 nM. It blocks ligand-stimulated activation of a chimeric EGFR-Mer protein. It also decreases colony-forming potential in rhabdoid and NSCLC tumor cells.

UNC2250 is an inhibitor of Mer receptor tyrosine kinase. It inhibits steady-state phosphorylation of endogenous Mer with an IC₅₀ of 9.8 nM. It blocks ligand-stimulated activation of a chimeric EGFR-Mer protein. It also decreases colony-forming potential in rhabdoid and NSCLC tumor cells.

B3111 | UNC2250 DataSheet

Alternate Name/Synonyms: 4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol; (1R,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol; trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-cyclohexanol

Appearance: White to off-white solid powder

Formulation:

CAS Number: 1493694-70-4

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₄H₃₆N₆O₂

Molecular Weight: 440.58

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Mer receptor tyrosine kinase

MDL Number: MFCD27992060

PubChem CID: 73211763

SMILES: CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C3=NC=C(C=C3)CN4CCOCC4

InChi: InChI=1S/C24H36N6O2/c1-2-3-10-25-24-27-16-21(23(29-24)28-19-5-7-20(31)8-6-19)22-9-4-18(15-26-22)17-30-11-13-32-14-12-30/h4,9,15-16,19-20,31H,2-3,5-8,10-14,17H2,1H3,(H2,25,27,28,29)

InChi Key: HSYSSKFCQHXOBP-UHFFFAOYSA-N