UNC45B Polyclonal Antibody | E-AB-18510

UNC45B Polyclonal Antibody | E-AB-18510 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Cardiomyopathy associated 4 , CMYA4 , FLJ38610, MGC119540, MGC119541, OTTHUMP00000163855, Protein unc 45 homolog B, Protein unc-45 homolog B, SMUNC45, Striated muscle UNC45, UN45B, Unc 45 homolog B (C. elegans), Unc 45 homolog B, UNC 45B, UNC-45B, UNC45 , UNC45B

Application: WB, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Developmental biology, Signal transduction

Background: This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.

Concentration: 0.8 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human UNC45B

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 104/95 kDa

Molecular Weight(Observed): Refer to figures