BW
UNC5A polyclonal Antibody | BS60730
- SKU:
- BW-BS60730
- Availability:
- Usually ships in 5 working days
Description
UNC5A polyclonal Antibody | BS60730 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: UNC5A polyclonal Antibody detects endogenous levels of UNC5A protein.
Molecular Weight: ~ 93 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Netrin receptor UNC5A; Protein unc-5 homolog 1; Protein unc-5 homolog A; UNC5A; KIAA1976; UNC5H1
Immunogen: A synthetic peptide corresponding to residues in Human UNC5A
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: