UNC5C Antibody (N-term) [APR13949G]

UNC5C Antibody (N-term) [APR13949G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This UNC5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the N-terminal region of human UNC5C.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Cell surface. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q761X5}. Cell projection, axon {ECO:0000250|UniProtKB:O08747}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08747}. Cell projection, growth cone {ECO:0000250|UniProtKB:O08747}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O08747}. Cell projection, filopodium {ECO:0000250|UniProtKB:O08747}

Molecular Weight: 103146

Clone: Polyclonal

Gene Name: UNC5C

Gene ID: 8633

Function: Receptor for netrin required for axon guidance (By similarity) . Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity) . NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977) . Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity) . Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity) . Also involved in corticospinal tract axon guidance independently of DCC (By similarity) . Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977) . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) .

Summary: Tissue Location: Mainly expressed in brain (PubMed:9782087) . Expressed in temporal lobe cortical neurons and in neurons of the hippocampal pyramidal layer (PubMed:25419706) . Also expressed in kidney (PubMed:9782087) . Not expressed in developing or adult lung (PubMed:9782087) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C, UNC5C, UNC5H3