uPA (L239) polyclonal Antibody | BS3454

uPA (L239) polyclonal Antibody | BS3454 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: The human urokinase-type plasminogen activator receptor (uPAR) is a 55-65 kDa, highly glycosylated, GPI-anchored cell surface receptor (the deglycosylated protein is 35 kDa) . It is a central player in the plasminogen activation pathway. uPAR binds with high affinity to a serine protease urokinase-type plasminogen activator (uPA) and converts plasminogen to its active form plasmin in a spatially restricted manner on the cell surface. Plasmin further carries out the activation of uPA, which is inhibited by serpins, such as plasminogen activator inhibitors. Therefore, uPAR plays a key role in regulating extracellular proteolysis. In addition, uPAR plays an important role in regulating cell proliferation, adhesion, and mobility. Research studies have shown that overexpression of uPAR is found in various cancer cells and tissues.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: uPA (L239) polyclonal Antibody detects endogenous levels of uPA protein.

Molecular Weight: ~ 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Urokinase-type plasminogen activator; U-plasminogen activator; Upa; PLAU

Immunogen: Synthetic peptide, corresponding to amino acids 211-260 of Human uPA.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phosphoinosotode Signaling,PI3K AKT signaling,Protein Kinase C Signaling,Warburg Effect,Tumor Angiogenesis,Translational Contral elF4 and p70 S6 Kinase,SAPK JNK Signaling Cascades,Inhibition of Apoptosis,Insulin &Glucose Signaling,G Protein-coupled Receptors Signaling to MAPK Erk,Adherens Junction signaling,Mitochondrial Control of Apoptosis,MTOR signaling,