UPK1A Antibody (C-term) [AMM08701G]

UPK1A Antibody (C-term) [AMM08701G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This UPK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-217 amino acids from the C-terminal region of human UPK1A.

Cellular Localisation: Membrane; Multi-pass membrane protein.

Molecular Weight: 28879

Clone: Polyclonal

Gene Name: UPK1A

Gene ID: 11045

Function: Component of the asymmetric unit membrane (AUM) ; a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity) .

Summary: Tissue Location: High expression restricted to ureteric urothelium (most superficial cells) ; low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Uroplakin-1a, UP1a, Tetraspanin-21, Tspan-21, Uroplakin Ia, UPIa, UPKa, UPK1A, TSPAN21