USP14 polyclonal Antibody | BS91412

USP14 polyclonal Antibody | BS91412 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB FC

Application Range: WB:1:500-1:1,000 FC:1:50-1:100

Background: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions. Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: USP14 polyclonal Antibody detects endogenous levels of USP14 protein.

Molecular Weight: 56 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: USP14, TGT, Deubiquitinating enzyme 14, TGT, tRNA guanine transglycosylase 60 kD subunit, tRNA guanine transglycosylase, Ubiquitin carboxyl terminal hydrolase 14, Ubiquitin carboxyl-terminal hydrolase 14, Ubiquitin specific peptidase 14, Ubiquitin specific processing protease 14, Ubiquitin specific protease 14, Ubiquitin thiolesterase 14, Ubiquitin-specific-processing protease 14, UBP14, USP 14, USP14,

Immunogen: Recombinant protein within human USP14 aa 200-450.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: